Parthenium hysterophorus, one of the world’s most invasive weeds, is accountable for enormous losses to the biodiversity, agriculture, and even the health of human beings and animals. It is regarded as immensely prolific weed and most awful in crop production which devastated all the useful crops. However, various studies revealed that Parthenium can be used in agriculture in different form. In agriculture, it can be used as biopesticides, green manure, compost, soil amendment values, and vermi composting. Being a competitive weed, it consumes more and more nutrients from the soil and hence, the plant is rich in nutrients. During premature stage, i.e. before flowering, the plant is uprooted from field and burying it in the soil produces higher quality organic manure. Green manure and compost used improves the physical, chemical and biological properties of soil, increased the yield of agricultural crops. Numerous studies show that it has also insecticidal and pesticidal properties to control several insect pests in agricultural crops. This review briefly discusses the application of Parthenium in agriculture concluded by various researchers.