This field experiment was carried out at the Agricultural Research Farm of the Institute of Agricultural Sciences, Banaras Hindu University, Varanasi during the Kharif season of 2016 and 2017. The experiment was established in a split-plot design with three replicates and comprised of total 15 treatment combinations involving three crop establishment methods (i) conventional till-direct seeded rice (ii) conventional till-wet direct-seeded rice (iii) and zero till-direct seeded rice in the main plot and five Zn application treatments (i) control (No Zn application) (ii) 3 kg Zn/ha (basal application) (iii) 3 kg Zn/ha (foliar application) (iv) 6 kg Zn/ha (basal application) (v) 6 kg Zn/ha (foliar application) in a subplot. Crop establishment methods significantly (p=0.05) influenced the density and dry weight of weeds at 20, 40, 60 and 80 days after sowing. Among crop establishment methods, conventional till-wet direct-seeded observed the lowest density and dry weight of grassy, sedge and broad-leaf weeds across all the crop growth stages. With respect to crop yield, conventional till-wet direct-seeded rice and 6 kg Zn ha-1 (basal application) recorded higher grain, straw and biological yield and harvest index. Thus, in conclusion, it is suggested that conventional till-wet direct-seeded rice and 6 kg Zn ha-1 (basal application) can be practised to record higher yields and effectively manage weeds in DSR.